Continuing Education (CE) for Endodontists
The continuing education article below is available to Endodontists and general dental practitioners who perform endodontics.
In order to earn continuing education credits, you must be a Free or Paid subscriber of Endodontic Practice US and complete a short quiz about the content of the article.
Our Free CE is limited to only 2 free credit hours per year. Click here if you would like to sign up for our free CE membership. Earn up to 16 online dental CE credits per year! Purchase a subscription now.
Educational aims and objectives
This clinical article aims to discuss research that related to the occurrence of post-endodontic pain after single-visit RCT using balanced force technique and two reciprocating system when AP is conserved.
Endodontic Practice US subscribers can answer the CE questions by taking the quiz to earn 2 hours of CE from reading this article. Correctly answering the questions will demonstrate the reader can:
- Observe that the incidence of post-endodontic pain is lower when apical patency (AP) ismaintained and presence/absence of preoperative pain has to be considered.
- Identify possible causes of post-endodontic treatment pain.
- Identify possible techniques to clean and shape the root canal.
- Identify the concept and benefits of balanced forces.
Drs. Jorge Paredes Vieyra, Fabian Ocampo Acosta, Francisco Javier Jiménez Enriquez, and Daniel Jiménez Zaragoza study post-operative pain when AP is conserved with the balanced force technique and two reciprocating systems.
Drs. Jorge Paredes Vieyra, Fabian Ocampo Acosta, Francisco Javier Jiménez Enriquez, and Daniel Jiménez Zaragoza sample 216 patients to analyze the occurrence of post-endodontic pain after single-visit RCT using balanced force technique and two reciprocating file systems
Post-endodontic pain is an ache after root canal treatment (RCT) and is described by more than 35% of patients regardless of periapical condition. Management of it is essential in endodontic practice (Ince, Ercan, Dalli, et al., 2009). Pain of endodontic origin is widely feared by the patients. Accurate information of pain occurrence and strictness related with pulpal or periradicular illness and its decrease by RCT has the possibility to change the attitudes of the patients, general dentists, endodontists, and other healthcare professionals (Watkins, Logan, Kirchner, 2002).
Debris, organic tissue, microbes, and irrigant solutions can be sent beyond the apex through RCT and can lead to postoperative problems such as intensive pain or flare-ups. Therefore, acceptable care of the working length (WL) may diminish the expulsion of remains through the apical foramen (AF) but may not avoid this entirely (Torabinejad, Kettering, McGraw, et al., 1988).
Accumulation of soft material remnant in the apex is a usual occurrence that can produce obstruction of the root canal (RC). This condition can be prevented if patency of the AF is maintained (Souza, 2006). Presently, maintaining apical patency (AP) is suggested through RCT (Monsef, Hamedzadeh, Soluti, 1997).
Apical patency is the action of using a tiny hand file to maintain the apical constriction (AC) open. It is a method that keeps the apex free of remains (Monsef, Hamedzadeh, Soluti, 1998). A patency instrument is described as a tiny bendable K-File, which is used through the AC (Fava, 1998; Buchanan, 1989). The instruments employed to gain AP are often the same instruments primarily used to negotiate RC (Izu, Thomas, Zhang, Izu, Michalek, 2004).
To improve cleaning and shaping of the canal, a technique such as the concept of balanced forces has been proposed (Roane, Sabala, Duncanson, 1985). The benefits of balanced forces (BF) are that these reduce the chance of change of WL, decrease canal alterations and formation of apical ledges (Monsef, Hamedzadeh, Soluti, 1997), permit maintenance of the integrity of the AC (Flanders, 2002), and increase the palpable appreciation of the professional through RCT (Buchanan, 1989).
Main improvements in mechanical shaping and metallic properties have led to the improvement of plentiful methods with novel designs in modern years. However, all methods and tools existing to this time are related with some level of expulsion of remains (Ferraz, Gomes, Gomes, et al., 2001; Bürklein and Schëafer, 2012).
The model of one-file for canal shaping was presented in endodontics (Yared, 2008) with the promotion of RECIPROC® (VDW®) tools (VDW, Munich, Germany). These metallic tools are made up of a nickel-titanium alloy named M-Wire by means of a novel thermal management procedure (Gutmann and Gao, 2012). The watch-winding motion comprises an initial turning of the device in a counterclockwise way during which the file enters and cuts the dentin and after that a sequence in the clockwise direction. Meanwhile, the file is liberated.
All root canal preparation techniques cause apical extrusion to some degree; however, the amount of extrusion may vary (Reddy and Hicks, 1998; Al-Omari and Dummer, 1995). Some other factors may disturb the occurrence of post-endodontic pain when AP was conserved in concordance to when it was not (Arias, Azabal, Hidalgo, de la Macorra, 2009).
One of the unproven details for not operating AP is the probable passage of remains throughout the AF, a clinical situation associated with post-endodontic pain (Ferraz, Gomes, Gomes, et al, 2001; Kirchhoff, Fariniuk, Mello, 2015). Some other authors have indicated that maintaining AP would not produce more postoperative complications, requiring it is reasonably made (Arias, Azabal, Hidalgo, de la Macorra, 2009).
The goal of this research was to relate the occurrence of post-endodontic pain after single-visit RCT using two reciprocating system and balanced force as control group when AP is conserved.
Materials and methods
This clinical research took place at the University Autonomous of Baja California, School of Dentistry, Tijuana, Mexico. The subjects review committee accepted the research, and the study was conducted in accordance with ethical principles (including the World Medical Association Declaration of Helsinki).
Three certified endodontists trained in the procedures, devices, and systems investigated took part in the research. All experts tracked a pre-established procedure for the balanced force technique, ProTaper Next™ (Dentsply Sirona), and RECIPROC® (VDW®) instrument systems.
The principal inclusion parameters were absence of radiographic sign of apical periodontitis and a diagnosis of irreversible pulpitis (IP) established by affirmative response to hot and cold examinations.
Thermal pulp examination was achieved by the corresponding author, and radiographic analysis was established by three certified endodontists. Clinical requirements were established on the following conditions:
- The purposes and necessities of the research were spontaneously
- Clinical management was pointed to patients in physical and mental well-being.
- All teeth had vital pulps and absence of apical periodontitis.
- Positive thermal stimulation with Endo-Ice® (Hygenic Corp., Akron, Ohio).
- Teeth with enough coronal structure for rubber dam isolation.
- No RCT done before the research.
- No painkillers or antibiotics used 7 days prior the clinical events started.
Exclusion parameters were the necessity for retreatment, gravidity, impossibility to obtain patient’s approval, patients who didn’t complete inclusion necessities, a history of medication for chronic pain or those compromising the immune response, patients younger than 18 years old, and the existence of mishaps or difficulties during RCT (calcified canals, impracticality of achieving AP in any canal). The subsequent records were collected in clinical archives. The judgment of vital tissue was established by accumulating dental records and doing digital radiography, periodontal assessment, percussion, and cold test. The diagnostic results were evaluated by relating the tooth’s reaction versus a contiguous tooth with the same vital condition.
This condition was rechecked by the presence of bleeding through the access. If the thermal test was positive and there was bleeding during endodontic access, the tooth was established as vital. The occurrence or nonexistence of preoperative pain (yes/no) was noticed. We requested whether the patients had pain or discomfort 7 days prior to the event. Teeth (posterior/anterior) and location (superior/inferior) were also added.
Two hundred and sixteen of 245 patients (119 women and 97 men) aged 18 to 65 years were incorporated in this research (Figure 1). Sample size estimate was achieved in accordance with a method for this specific purpose (Cochran’s method, 1986). Therefore, the 72 teeth allocated to each group were adequate to confirm an essential sample. All patients had upper or lower molar, premolar, or anterior teeth selected for conventional RCT for prosthetic reasons detected with vital pulps. Clinical cases with nonvital teeth and apical periodontitis, endodontic retreatment, root resorption, undeveloped apex, or a root canal with severe curvature (>35º) or a radiographically untraceable canal path were all rejected from the study (shown in Figure 1). Patients opting to reject the research, those with issues with single-visit RCT, those consuming a specific kind of medicine such as painkillers or NSAIDs, and participants with some unrestrained systemic ailment were excluded as well. All participants were knowledgeable of the goals and strategy of the study, and written permissions were gained prior to their addition.
Random selection of instrumentation groups
Of the sample of 216 teeth, 72 were selected to the three instrumentation methods. The study strategy included three experts, and each expert prepared 72 teeth, 24 per technique.
All patients were anesthetized with two carpules of articaine 2% with epinephrine 1:200,000 (Septodont, Saint-Maur des-Fosses, France). In cases in which supplemental anesthesia was needed, intraligamental articaine 2% was injected. After absolute isolation, the tooth was sanitized with 5.25% NaOCl.
Cavity access was performed by using No. 331 bur (Dentsply International, York, Pennsylvania), with high speed and water cooling during the procedure. 5.25% NaOCl was used to clean the coronal cavity. The canals were evaluated with No. 10 K-type hand files (Flex-R® files, Moyco Union Broach, York, Pennsylvania).
The standard method involved the following steps: Access was achieved, and REDTA (Roth International, Chicago, Illinois) lubricant was placed at the entry of the canals. Determination of WL was first determined with a No. 15 K-File and the Root ZX electronic device (J. Morita, Irvine, California), followed by subtracting 0.5 mm from the measurement, which was calculated with the assistance of a metallic ruler and digital radiographic confirmation (Schick Technologies, New York). A glide path to the WL was then established.
The pulpal cavity was dried with a sterilized cotton pellet. Lubricant was positioned at the entry of canals (i.e., measurements were made along humid canals). A No. 15 file attached to Root ZX apex locator was used to calculate WL, which was calculated with No. 20 and No. 25 files, respectively. If there was no arrangement among measures obtained by using the three files, the data that was dissimilar was reevaluated. If the discrepancy continued, the measure conveyed with the thicker file was designated. WL was confirmed with a digital radiograph. In the event of dissimilarity between radiographic and electronic quantities, the last was designated.
For hand instrumentation, balanced force was used. All canals were cleaned and shaped with hand Flex-R files (Moyco Union Broach, York, Pennsylvania). Gates Glidden burs (Dentsply Maillefer) sizes No. 2 and No. 3 were used at the entry of the canals. For mechanical shaping, all instruments were used with a micro motor (VDW Silver RECIPROC motor). Torque and rotation were established independently for each instrument method used. ProTaper Next and RECIPROC instruments were used in continuous brushing rotary motion and reciprocating mode, respectively.
Dentinal remains were eliminated from the file by means of a gauze, simultaneously to the next instrument change (ProTaper Next system) or after two or three in-and-out (pecking) movements (RECIPROC systems) according to the manufacturer’s commendations. Each root canal was irrigated with 2.5mL 2.6% NaOCl. Irrigation was achieved using a 24-gauge needle (Max-i-Probe®; Tulsa Dental, York, Pennsylvania) through access and a 31-gauge NaviTip™ needle (Ultradent Products Inc., South Jordan, Utah) when getting the WL after each instrument insertion.
Group BF. For the balanced force group, the root canals were cleaned and shaped using a No. 40 instrument for thin or curved canals and a No. 55 file for widespread canals.
Group PTN. For the ProTaper Next group, SX files, X1 and X2 (ProTaper Universal System; Dentsply, Ballaigues, Switzerland) were used for preflaring and preparation of thin and curved canals and X3 and X4 (40.06) for preparation of wide canals up to the WL. The instruments were operated using a continuous rotary brushing motion at a speed of 300 rpm and a torque of 2 Ncm.
Group R. R25 (25.08) instrument was used in thin and curved RC, and R40 files (40.06) were used in wide canals. Three in-and-out motions were used with lengths not beyond 3 mm in the three thirds of the canal until reaching the estimated WL. Hand and rotary files were employed in just one tooth (single use) and then excluded. AP was conserved through all the procedures used by using a No. 10 K-type file at WL.
After the instrumentation phase, the pulp chamber was rinsed with 1 mL 2.6% NaOCl, agitated ultrasonically. Ultrasonic activation was performed using an Irrisafe™ ultrasonic 20.00 tip (Satelec, Merignac, France) at 50% power of the MiniEndo™ ultrasonic unit (Kerr Endo) to place the tip 3 mm from the WL for 30 seconds per canal. Then each experimental group received a final irrigation with cold (8ºC) 17% EDTA gently delivered to the WL using a cold (8ºC) sterile metallic microcannula attached to the EndoVac™ negative pressure irrigation system (Kerr Endo) for 3 minutes to eliminate the smear layer and reduce post-endodontic pain. Caution was taken to ensure that the microcannula would suction correctly by detecting the system’s transparent evacuation tube. In case of any obstruction, the microcannula was instantly substituted.
Repeat of WL was established again by using EAL as described previously, using No. 35, No. 40, and No. 45 files. The root canals were then desiccated with disinfected paper cones and filled at the same visit. Gutta-percha cones (Dentsply Maillefer) were laterally compacted with No. 20 nickel-titanium spreaders (Dentsply Maillefer) and AH Plus sealer (Dentsply Maillefer). Entrance openings of anterior teeth were etched and repaired with Fuji IX (GC Corp., Tokyo, Japan). For posterior teeth, a rebuilding was placed with the same method.
Assessment of post-endodontic pain and statistical analysis
Patients were informed of the probable incidence of pain for days following RCT and received a survey form to be finished and returned 3 days after. In it, they provided proof of the occurrence or nonappearance of post-endodontic pain, its period and level of distress rated as follows: mild pain — any discomfort of any duration that does not require treatment; moderate pain — pain that requires and is relieved with analgesics; and severe pain — any pain that is not calmed with treatment (analgesics).
Some 210 of the 216 surveys were returned correctly with responses and on the date requested. Of these, 69 belonged to BF group, 70 to PTN group, and 71 to R group. The rest of the 216 were received 1 day after and were included in the data analysis.
Outcomes of groups BF, PTN, and R associated with occurrence (yes/no), level (mild, moderate, severe), and interval (days) of post-endodontic ache were evaluated, focusing to diagnostic factors: condition of tooth (all vital), occurrence or nonappearance of preoperative pain, group of teeth (molar/premolar or anterior), or location (maxillary, mandibular). Outcomes were examined with the Chi-Square for the occurrence of post-endodontic pain and Mann-Whitney U test.
The clinical structure of the participants is shown in Table 1. The average age of the 216 participants registered in this research was 54 years. No statistically significant difference (p > .05) among the groups was found regarding degree or duration of pain. The post-endodontic pain marks were seen 24 hours later in the three groups with an important decline subsequently.
No statistically important difference was seen between the three groups evaluated in the research in terms of level and amount of analgesic medicine consumption (p > .05, Tables 2 and 3). In general, analgesic consumption was limited to the next 24 hours after RCT in all the groups evaluated. None of the 216 patients stated acute pain or flare-ups during the phase of the research (Table 4).
In situations with informed occurrence of preoperative pain, periods of post-endodontic pain were considerably more. There was no statistically significant difference (p> .05) among the Balanced Force technique, PTN, and R techniques in relation to the occurrence of post/endodontic ache at any of the three time points measured (Tables 3 and 4).
Group of teeth
No statistically significant differences were encountered between groups about occurrence, grade, or length of post-endodontic pain among anterior and posterior teeth.
Post-endodontic pain associated to the arch
In maxillary teeth, differences among groups were not statistically relevant concerning occurrence, level, or length of post-endodontic pain. In mandibular teeth, post-endodontic pain was significantly lengthier (P .016; Table 3) than maxillary teeth.
Pain by itself is difficult to understand and measure, especially when it happens suddenly in patients. The principal difficulties in learning aching and discomfort are the participants’ idiosyncratic assessment and its dimension. For this purpose, planning the evaluation form has to be completely comprehended by participants.
In our research, a simple spoken classification was followed in the feedback procedure with three classes: minor, modest, and acute. These classes were clearly comprehended by participants and were described by the occurrence or nonappearance of the necessity for pain-relieving treatment. Preoperative pain is one of the highest predictors of post-endodontic pain (Glennon, Ng, Setchell, et al., 2004). Thus, only teeth with IP indicated for RCT because of prosthodontic purposes were chosen for this research.
All treatments were performed in one visit to avoid any the possible influence of intracanal medication or other issues generating pain, and all the teeth in the three groups were released of any early occlusal points after endodontic procedures so that unsuitable traumatic occlusion would not disturb the outcomes.
In this research, correct measure of WL during RCT was furthermore crucial. WL was estimated with an EAL and confirmed with a radiograph. Root ZX EAL was employed because its exactitude has been established in two clinical environments (Luiz, et al., 2006; Tselnik, et al., 2006; Welk, et al., 2003; Dunlap, et al., 1998). As suggested by Herrera, et al. (2007), electronic WL measurement was repetitive after cervical and middle thirds shaping.
When clinicians combine radiographic interpretation and digital RC dimensions, occasionally, outcomes do not match. In the occasion of inconsistency among both magnitudes, the electronic assessment would be chosen (Lucena-Martín, et al., 2004; Kim-Park, et al., 2003; Williams, et al., 2006), as in this study.
A recent study (Caillateau and Mullaney, 1997) demonstrated that the dimension of the file employed to preserve AF open varied. We methodically used a No. 10 width file to maintain AP in this study. Operating major widths to maintain AP can produce damage of surrounding tissues, hard control in complete RCT. All of these situations predispose the occurrence of post-endodontic pain.
It is well-known that forcing of endodontic files outside the AF can send a diversity of toxic materials to the surrounding tissues, which can generate pain (Nobuhara, et al., 1993). Georgepoulou, et al. (1986), showed a significantly major occurrence of pain if through the modeling procedure, instruments or material were involuntary placed outside the AF instead of maintaining them inside the canal (Georgepoulou, et al., 1986). In our protocol, there is no over-instrumentation; AP was maintained in all cases. Nevertheless, AP does not appear to be related to post-endodontic pain in vital condition because of its control during RCT (Fox, et al., 1970).
Furthermore, Torabinejad, et al. (1988), stated that if inadvertent over-passage of the instrument occurs while determining WL, this doesn’t interfere with the incidence of post-endodontic pain. Our methodology was similar to them because likely we employed only thin files to establish the WL. This study supports our results in that apical over-extension does not generate post-endodontic pain, though it varies from our research in that they didn’t maintain AP during all the RCT.
Siqueira, et al. (2002), discovered little frequency of flare-ups following RCT in teeth with necrotic tissue or teeth with previous RCT if AP was maintained. They identified that maintenance of AP does not affect post-endodontic pain. This was not measured in our research. In our report, we did not treat clinical cases for retreatment procedures, and flare-ups were not evaluated.
In our research, we reduced the variation in the procedures following protocols based on recommendations by authors and manufacturers. Clean and shape procedures were performed on root thirds using brushing and reciprocating movements, respectively, followed a final irrigation with cold (8ºC) 17% EDTA gently delivered to the WL using a cold (8ºC) sterile metallic microcannula attached to the EndoVac™ supported in an early scientific report (Modabber, et al., 2013; Bleakley, et al., 2006; Al-Nahlawi, et al., 2016).
The incidence of post-endodontic pain is lower when AP is maintained, and presence/absence of preoperative pain has to be considered. When previous symptoms are present, occurrence and period of pain is longer in teeth with this condition that when AP is maintained. It can be established that conserving AP with a thin K-File can help to prevent post-endodontic pain in some specific cases.
Besides the balanced force technique, Dr. Vieyra has written an article comparing working length determination during RCT. Read his evaluation of two apex locators here: https://endopracticeus.com/ce-articles/comparison-working-length-determination-root-canal-treatment/
- Al-Nahlawi T, Hatab TA, Alrazak MA, Al-Abdullah A. Effect of intracanal cryotherapy and negative irrigation technique on post endodontic pain. J Contemp Dent Pract. 2016;17(12):990-996.
- Al-Omari MAO, Dummer PMH. Canal blockage and debris extrusion with eight preparation techniques. J Endod. 1995;21(3):154-158.
- Arias A, Azabal M, Hidalgo JJ, de la Macorra JC. Relationship between post endodontic pain, tooth diagnostic factors, and apical patency. J Endod. 2009;35(2):189-192.
- Bleakley CM, McDonough SM, MacAuley DC, Bjordal J. Cryotherapy for acute ankle sprains: a randomized controlled study of two different icing protocols. Br J Sports Med. 2006;40(8):700-705.
- Buchanan LS. Management of the curved root canal. J Calif Dent Assoc. 1989;17(4):18-27.
- Bürklein S, Schëafer E. Apically extruded debris with reciprocating single-file and full-sequence rotary instrumentation systems. J Endod. 2012;38(6):850-852.
- Caillateau J, Mullaney T. Prevalence of teaching apical patency and various instrumentation and obturation techniques in United States dental schools. J Endod. 1997;23(6):394-396.
- Dunlap CA, Remeikis NA, BeGole EA, Rauschenberger CR. An in vivo evaluation of an electronic apex locator that uses the ratio method in vital and necrotic canals. J Endod. 1998;24(1):48-50.
- Fox J, Atkinson J, Dinin A, et al. Incidence of pain following one-visit endodontic treatment. Oral Surg. 1970;30(1):123-30.
- Fava L. Acute apical periodontitis: incidence of post-operative pain using two different root canal dressings. Int Endod J. 1998;31(5):343-347.
- Ferraz CC, Gomes NV, Gomes BP, et al. Apical extrusion of debris and irrigants using two hands and three engine-driven instrumentation techniques. Int Endod J. 2001;34(5):354-358.
- Flanders D. Endodontic patency: how to get it, how to keep it, why it is so important. N Y State Dent J. 2002;68(3):30-32.
- Georgepoulou M, Anastassiadis P, Sykaras S. Pain after chemomechanical preparation. Int End J. 1986;19(6): 309-314.
- Glennon JP, Ng YL, Setchell DJ, Gulabivala K. Prevalence of and factors affecting post preparation pain in patients undergoing two-visit root canal treatment. Int Endod J. 2004;37(1):29-37.
- Gutmann JL, Gao Y. Alteration in the inherent metallic and surface properties of nickel-titanium root canal instruments to enhance performance, durability and safety: a focused review. Int Endod J. 2012;45(2):113-128.
- Herrera MC, Abalos A, Planas J, Llamas R. Influence of apical constriction diameter on Root ZX apex locator precision. J Endod. 2007;33(8):995-998.
- Ince B, Ercan E, Dalli M, et al. Incidence of postoperative pain after single- and multi-visit endodontic treatment in teeth with vital and nonvital pulp. Eur J Dent. 2009;3(4):273-279.
- Izu KH, Thomas SJ, Zhang P, Izu AE, Michalek S. Effectiveness of sodium hypochlorite in preventing inoculation of periapical tissues with contaminated patency files. J Endod. 2004;30(2):92-94.
- Kim-Park MA, Baughan LW, Hatwell GR. Working length determination in palatal roots of maxillary molars. J Endod. 2003;29(1):58-61.
- Kirchhoff AL, Fariniuk LF, Mello I. Apical extrusion of debris in flat-oval root canals after using different instrumentation systems. J Endod. 2015;41(2):237-241.
- Lucena-Martín C, Robles-Gijón V, Ferrer-Luque CM, de Mondelo JM. In vitro evaluation of the accuracy of three electronic apex locators. J Endod. 2004;30(4):231-3.
- D’Assunção FL, de Albuquerque DS, de Queiroz Ferreira LC. The ability of two apex locators to locate the apical foramen: an in vitro study. J Endod. 2006;32(6):560-562.
- Modabber A, Rana M, Ghassemi A, et al. Three-dimensional evaluation of postoperative swelling in treatment of zygomatic bone fractures using two different cooling therapy methods: a randomized, observer-blind, prospective study. 2013;14:1-10.
- Monsef M, Hamedzadeh K, Soluti A. Effect of apical patency on the apical seal of obturated canals. J Endod. 1997;23(4):253.
- Monsef M, Hamedzadeh K, Soluti A. Effect of apical patency on the apical seal of obturated canals. J Endod. 1998;24:284.
- Nobuhara W, Carnes D, Gilles J. Anti-inflammatory effects of dexamethasone on periapical tissues following endodontic overinstrumentation. J Endod. 1993;19(10):501-507.
- Reddy SA, Hicks ML. Apical extrusion of debris using two hands and two rotary instrumentation techniques. J Endod. 1998;24(3):180-183.
- Roane JB, Sabala CL, Duncanson MG Jr. The “balanced force” concept for instrumentation of curved canals. J Endod. 1985;5(11):203-211.
- Siqueira J, Rôças I, Favieri A, et al. Incidence of postoperative pain after intracanal procedures based on an antimicrobial strategy. J Endod. 2002;28(6):457-460.
- Souza RA. The importance of apical patency and cleaning of the apical foramen on root canal preparation. Braz Dent J. 2006;17(1):6-9.
- Torabinejad M, Kettering J, McGraw J, et. al. Factors associated with endodontic interappointment emergencies of teeth with necrotic pulps. J Endod. 1988;14(5):261-266.
- Torabinejad M, Kettering JD, McGraw JC, et al. Factors associated with endodontic interappointment emergencies of teeth with necrotic pulps. J Endod. 1998;14:261-6.
- Tselnik M, Baumgartner J, Gordon Marshall J. An evaluation of Root ZX and Elements Diagnostic apex locators. J Endod. 2006;31(7):507-509.
- Watkins CA, Logan HL, Kirchner HL. Anticipated and experienced pain associated with endodontic therapy. J Am Dent Assoc. 2002;133(1):45-54.
- Welk A, Baumgartner J, Gordon Marshall J.2003; An in vivo comparison of two frequency- based electronic apex locators. J Endod. 2003;29(8):497-500.
- Williams CB, Joyce AP, Roberts S. A comparison between in vivo radiographic working length determination and measurement after extraction. J Endod. 2006;32(7):624-627.
- Yared G. Canal preparation using only one Ni-Ti rotary instrument: preliminary observations. Int Endod J. 2008; 41(4):339-344.